Endocrine Abstracts

Chloroquine, the commonly used in the treatment of malaria has been reported to elicit adverse effects such as hypoglycaemia through unknown mechanisms. In particular, literature to date has revealed that the effects of the drug on insulin concentrations remain obscure. Our investigation therefore focuses on establishing a possible mechanism of CHQ-induced hypoglycaemia with regards to its effects on plasma insulin concentrations. The purpose of this study was to investigate t...

Chloroquine (CHQ) the most frequently used drug for falciparum malaria in sub-Saharan Africa countries evokes adverse effects on glucose homeostasis and kidney function in African children. The complications can partly be ascribed to transiently high plasma CHQ concentrations following oral administration and/or malaria parasites. We have, however, reported that topical application of the pectin CHQ matrix patch releases CHQ into the bloodstream. Accordingly, the curr...